From Sault Ste Marie, travel east on Highway 17 until you reach Espanola. Turn right on Highway 6 and travel south until you reach Little Current, just past the swing bridge. Turn left at Highway 6 at Little Current and proceed south, until you reach the town of Manitowaning. At Manitowaning, follow the Wikwemikong signs.
From Tobermory, take the Chi Cheeman Ferry across Georgian Bay (from the Tobermory ferry terminal) to Southbay Mouth on Manitoulin Island. Continue to travel north on Highway 6 until just before you reach Manitowaning. Turn right at the Wikwemikong sign, then right again at the next Wikwemikong sign at the foot of the hill. Continue for another 10 minutes to Wikwemikong.